The National Institutes of Health has awarded a $2.5 million translational research grant over five years to Noelle Moreau, PhD, PT, associate professor of physical therapy at LSU Health New Orleans School of Allied Health Professions, to study the effectiveness of a highly innovative approach to improve the ability of children with cerebral palsy to walk. Dr. Moreau will investigate the effects of Power Training combined with Interval Treadmill Training, known as PT3, on functional walking capacity, muscle performance, and architecture. PT3 is a combined impairment and task-specific approach, which targets muscle power deficits, specifically.
“Current rehabilitation practice uses motor learning principles related to specificity of practice, or task-specific training, for improving walking in those with neurological disorders, such as cerebral palsy,” noted Moreau. “This traditional singular approach fails to address the underlying muscular mechanisms responsible for the walking limitations and has not been shown to be more effective than other therapies in people with spinal cord injury, stroke, and cerebral palsy. In this intervention, we will address muscle power, a key ingredient that is missing from current clinical practice for children with cerebral palsy, and combine it in a package of care with a task-specific training protocol that allows the participants to practice using muscle power generation during the functional task of walking.”
The study, funded by the NIH’s National Institute of Child Health and Human Development, seeks to determine the immediate and retention effects of PT3 on functional walking capacity in ambulatory children with cerebral palsy; quantify the effects of treatment on muscle architecture and performance; and directly capture the effect of treatment on community-based walking activity and participation using novel, mobile-sensing technology.
The LSU Health New Orleans site of the multi-center clinical trial will enroll 24 ambulatory children with cerebral palsy who are between the ages of 10 and 17. Participants will be randomly assigned to receive either PT3 or an equivalent dosage of traditional strength training combined with traditional treadmill training for 24 sessions, three times per week for eight weeks.
Cerebral palsy (CP) is a nonprogressive developmental disorder of movement and posture that leads to activity limitation caused by damage to the immature brain before, during, or shortly after birth. CP occurs in 3.6 per 1,000 live births or 1 in 278 children, according to the Centers for Disease Control and Prevention, and is the most common physical disability originating in childhood. The CDC reports the incidence of CP is higher than childhood cancer, hearing, and vision loss, spina bifida, hemophilia, fetal alcohol syndrome, and cystic fibrosis. Although the initial brain insult is nonprogressive, CP is a lifelong disorder due to secondary musculoskeletal problems and associated activity limitations that progress into adulthood. Gait disturbances are an activity limitation that is a hallmark characteristic of CP. Walking ability significantly deteriorates in 50% of ambulatory children with CP beginning in childhood/adolescence. Of those who stop walking, 75% will lose the ability to walk before the age of 25, severely impacting their ability to participate in daily life.
“This intervention represents a paradigm shift in clinical practice by addressing the specific underlying muscular mechanisms responsible for walking limitations in this group, incorporating task-specific training of walking, and focusing on developmentally appropriate pediatric walking activity patterns, rather than adult patterns, that require muscle power to be generated through high-speed intervals,” said Moreau.
Moreau plans to begin enrolling participants in the next month or so. For more information, and to get on a waiting list, contact Dr. Noelle Moreau at (504) 568-4291 or Nmorea@lsuhsc.edu.